The incidence of multiple primary malignant neoplasm(MPMN) in an individual is in gradual and steady increase with the time as reported in many literature. This increase has been attributed to the fact that the average lifespan of cancer patients
was
remarkably prolonged with a striking development of cancer surgery, postoperative adjuvant therapy, and diagnostic and interventional radiology. Authors reviewed forty seven patients with multiple primary malignant neoplasm among 5,534 cancer
patients
registered in Pusan Paik Hospital from 1980 to 1993.
The overall incidence of multiple primary malignant neoplasm was 0.84%, synchronous neoplasm was 29 cases and metachronous was 18 cases. The sex ratio of male to female was 1.2 : 1. The mean age of the patients with synchronous neoplasm at
diagnosis was
57.4years old and metachronous neoplasm at first cancer was 48.5 years old. In metachronous neoplasm, the mean time interval between 1st and 2nd neoplasm was 67 months. There was one familial MPMN affected by stomach and colon cancer. The most
frequent
combination site was stomach and colorectal cancer. Blood group A was most common in synchronous and metachronous neoplasm (55%).
Therefore, in order to get longer survival period in cancer patients, it is important to make early detection of second cancer in same patient with careful follow-up and examination, and to avoid the exposure of the carcinogenic material in the
high-risk patients, based on awareness of the possibility of second cancer.
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